Blar i Bergen Open Research Archive på forfatter "Sverkeli, Lars Jansen"

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    • The 2021 FASEB science research conference on NAD metabolism and signaling 

      Gorbunova, Vera; Buschbeck, Marcus; Cambronne, Xiaolu A.; Chellappa, Karthikeyani; Corda, Daniela; Du, Juan; Freichel, Marc; Gigas, Jonathan; Green, Alexander E.; Gu, Feng; Guberovic, Iva; Jayabalan, Aravinthkumar; Khansahib, Imrankhan; Mukherjee, Sarmistha; Seluanov, Andrei; Simon, Matthew A.; Sverkeli, Lars Jansen; Kory, Nora; Levine, Daniel C.; Matic, Ivan; Nikiforov, Andrey; Rack, Johannes G.M.; Imai, Shin-Ichiro; Sinclair, David A.; Toiber, Debra; Zhao, Yongjuan; Mostoslavsky, Raul; Kraus, Lee; Guse, Andreas H. (Journal article; Peer reviewed, 2021)

    • The balance between NAD+ biosynthesis and consumption in ageing 

      Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...

    • Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD 

      Sverkeli, Lars Jansen; Hayat, Faisal; Migaud, Marie E.; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is ...

    • Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication 

      Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge; Bergersen, Linda H.; Esbensen, Qin Ying; Sverkeli, Lars Jansen; Ziegler, Mathias; Attramadal, Håvard; Halvorsen, Bente; Aukrust, Pål; Yndestad, Arne (Journal article; Peer reviewed, 2021)
      Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation ...

    • The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease 

      Brakedal, Brage; Dölle, Christian; Riemer, Frank; Ma, Yilong; Nido, Gonzalo Sanchez; Skeie, Geir Olve; Craven, Alexander R.; Schwarzlmüller, Thomas; Brekke, Njål; Diab, Joseph; Sverkeli, Lars Jansen; Skjeie, Vivian; Varhaug, Kristin Nielsen; Tysnes, Ole-Bjørn; Peng, Shichun; Haugarvoll, Kristoffer; Ziegler, Mathias; Grüner, Renate; Eidelberg, David; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
      We conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), is safe, augments cerebral NAD levels, ...